Harvey Weinstein's wife, Georgina Chapman, has announced that she is leaving the movie mogul after a string of woman claimed that he had sexually harassed or assaulted her.
'My heart breaks for all the women who have suffered tremendous pain because of these unforgivable actions. I have chosen to leave my husband,' she told People.
'Caring for my young children is my first priority and I ask the media for privacy at this time.'
At the same time as Chapman made the announcement, Weinstein made a departure of his own - to Europe, by private jet.
There he will undergo therapy for sex addiction and behavioral issues, TMZ reported.
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Georgina Chapman, 41, announced she is leaving husband Harvey Weinstein, 65, (both pictured in February) on Monday, five days after he said she was '100 per cent' behind him
Chapman (seen left on Friday) made the remark as it emerged that Weinstein (right) was flying to Europe for sex rehab. Chapman reportedly relied on him to promote her fashion company
Weinstein will submit himself to a live-in facility, in which he hopes he will be able to clean up his act and return to the US.
According to TMZ's source, the hotheaded producer is surprisingly calm about the chaos that has beset him this week.
'He has his moments where there are bursts, but for the most part he's pretty calm,' the insider said.
Weinstein also hopes that he will still be able to serve the Weinstein Company, from which he was fired by the board on Sunday, in some capacity.
His legal team are in talks with the company, and according to an insider, he 'wants to come back with fresh, new ideas'.
Chapman, 41, met Weinstein, 65, in 2003 and they married four years later, going on to have two children, India Pearl, seven, and Dashiell Max Robert, four.
She is also the co-founder of high-end women's fashion line Marchesa - and before the announcement of her split from Weinstein, sources said that she was struggling to save the brand from being tarnished by her husband's allegations.
But leaving him might present other problems for the beleaguered British designer.
Among the women who have accused Weinstein of assault or harassment are actresses Rose McGowan (left) and Ashley Judd (right)
Chapman is reportedly concerned that his past will affect her fashion company, Marchesa - but also worried that without him she won't have the A-list connections to ensure the brand remains high-profile. The couple are seen here in 2012
A source told People that she is terrified that the line, which is loved by many of the women who have starred in her husband's films, will founder without his help.
That's because he - as one of the heaviest hitters in Hollywood - has access to the A-list stars that can keep the brand in the public eye.
A TV fashion source said: 'Harvey is the one with all the friends. It's going to be a tough time for her and Marchesa'.
A New York fashion publicist who did not want to be named told the Hollywood reporter: 'No star is ever going to want to wear the brand again.'
Weinstein is good friends with Vogue editor Anna Wintour and the two have co-hosted fashion and Democratic political fundraising events.
Chapman and Weinstein are regular guests at Wintour's annual Metropolitan Museum of Art Costume Institute galas.
Chapman's departure will likely come as a shock to Weinstein, who had boasted last week that his wife was 'standing by me 100 per cent'.
He has also said she will be one of the people to 'kick my a**' and help him become a better man.
The couple were yesterday said to be holed up in a Los Angeles hotel together.
The Weinstein controversy showed no signs of winding down on Tuesday, as several new actresses came forward to detail how Weinstein had assaulted them.
Anglina Jolie said that in 1998, when she was just 23 and promoting her film 'Playing By Heart', Weinstein made unwanted advances on her in a hotel room.
On Tuesday Gwyneth Paltrow (left, with Weinstein in 1999) said he sexually harassed her when she was 22. Angelina Jolie (right) said he did the same, so she never worked with him again
Asia Argento (above in 2004) said that Harvey Weinstein raped her in a hotel room at the Hotel du Cap-Eden-Roc back in 1997. Three other women also accused him of rape
'I had a bad experience with Harvey Weinstein in my youth, and as a result, chose never to work with him again and warn others when they did,' Jolie told The New York Times.
'This behavior towards women in any field, any country is unacceptable.'
Her voice was joined by that of Gwyneth Paltrow, who said that Weinstein sexually harassed her at his Beverly Hills hotel when she was just 22, and that it almost lost her a big role.
Italian star Asia Argento told the New Yorker that Weinstein raped her in 1997 at a party hosted by Miramax at the Hotel Du Cap-Eden-Roc.
She claims the mogul led her to an empty room and asked her to give him a massage.
She reluctantly agreed,and halfway through he began to perform oral sex on her after forcibly lifting up her skirt despite her repeated requests for him to stop, she said.
Aspiring actress Lucia Evans and another unnamed woman accused him of rape as well, according to the article.
Rosanna Arquette and Mira Sorvino also said that Weinstein forced himself upon them, but that they were able to fight off his sexual advances.
Soon after, the two women say, their careers began to suffer.
Also on Tuesday, actors Ben Affleck and Matt Damon finally spoke out about Weinstein, who was instrumental in bagging them an Oscar for Good Will Hunting.
Rosanna Arquette (left) and Mira Sorvino (right) both said Weinstein forced himself on them, but that they managed to fight him off
Ben Affleck finally broke his silence to condemn Harvey Weinstein on Tuesday, saying the sexual harassment claims made him sick. Weinstein produced Good Will Hunting, for which Affleck and Matt Damon (all three pictured) won a Best Original Screenplay Oscar
Affleck only made the remarks after five days of widespread condemnation of Weinstein - and after being asked repeatedly for comment by DailyMail.com
Affleck, who had been silent on the matter for five days, finally said on Facebook that he was 'saddened and angry' over the claims.
'I am saddened and angry that a man who I worked with used his position of power to intimidate, sexually harass and manipulate many women over decades,' he wrote.
'The additional allegations of assault that I read this morning made me sick,' he added, calling them 'unacceptable' and demanding people 'do better at protecting' women.
Those remarks didn't impress Rose McGowan, one of Weinstein's alleged victims, who accused him of knowing about his abuses for at least 20 years.
She tweeted: '@benaffleck "GODD*MNIT! I TOLD HIM TO STOP DOING THAT" you said that to my face. The press conf I was made to go to after assault. You lie.'
She then tweeted a screengrab of her message onto her main timeline with the message: 'You want to play let's play #ROSEARMY.'
Although Affleck implied that he had only just learned of the Weinstein claims, McGowan said she'd told him after her alleged 1997 assault and that he was aware of previous allegations
It's not clear which press conference McGowan was referring to, but both she (left) and Affleck (center) appeared in the 1998 horror movie Phantoms (pictured), produced by Weinstein
It's not clear which press conference she was referring to, but both McGowan and Affleck appeared in the 1998 movie Phantoms, which was executive-produced by Weinstein.
The horror flick premiered at the 1997 Sundance Film Festival, which is where McGowan's alleged assault took place.
Good Will Hunting premiered in December of that year; two of Affleckes preceding three films - Kevin Smith comedies Mallrats and Chasing Amy - were also backed by Weinstein.
McGowan also tweeted 'Ben Affleck f*** off'.
She had been prodding the Batman star for days to speak out, but clearly she hoped for a different response.
On Monday, she tweeted: 'Ben Affleck Casey Affleck, how's your morning boys?'
Casey Affleck has also been accused of sexual harassment.
Immediately after his remarks, McGowan also tweeted 'Ben Affleck f**k off'
Shortly after Affleck's statement came out, The New York Times published a story revealing that both Gwyneth Paltrow and Angelina Jolie were subjected to unwanted advances by the Hollywood heavyweight.
Affleck and Paltrow dated briefly in the late '90s. Paltrow was dating Brad Pitt around the time Weinstein made advances towards her.
Also addressing the controversy on Tuesday was Matt Damon, whom McGowan had previously called a 'spineless profiteer who stays silent'.
Damon (pictured with Weinstein in 1998, the year Good Will Hunting was released) spoke out just after Affleck did, claiming that he had no idea of the producer's actions
He and Russell Crowe had been accused by The Wrap's Susan Waxman of intervening in a story she was writing on Weinstein.
It claimed Fabrizio Lombardo, the former head of Miramax Italy was put on the payroll to procure women for Weinstein. Lombardo denied the claims at the time.
While she was working on the story, Waxman says the actors called her to vouch for Lombardo and the allegations about Weinstein were stripped out of the piece by her editors.
Damon, who said he knew Lombardo from the Italian launch of The Talented Mr Ripley, said he had no idea about what Waxman was investigating.
'Harvey said, "Sharon Waxman is writing a story about Fabrizio and it’s really negative. Can you just call and tell her what your experience with Fabrizio was?" So I did, and that’s what I said to her,' Damon said.
'For the record, I would never, ever, ever try to kill a story like that. I just wouldn’t do that. It’s not something I would do, for anybody,' Damon said.
Waxman has since spoken out to say that she 'endorses' Damon's side of the story, tweeting Tuesday that he 'wasn't informed' on the sexual harassment allegations.
Also drawn into the ongoing story on Tuesday was Weinstein's first wife, Eve Chilton, after Heather Graham said she had been aware Weinstein slept with other women.
Graham said that in a meeting with Weinstein in the early 2000s, the movie mogul bragged that he and his wife had an 'agreement' that he could sleep with whoever he wanted to while he was out of town. He was speaking of his first wife Eve Chilton, who he is pictured with in 1997. The two divorced in 2004
Graham told Variety that in the early 2000's she met Weinstein at his office and was told that he wanted to cast her in one of his movies - offering her a pile of scripts on his desk to pick from.
'Later in the conversation, he mentioned he had an agreement with his wife,' Graham said, referring to Chilton, whom Weinstein married in 1987 and divorced in 2004.
'[He said] He could sleep with whomever he wanted when he was out of town,' she said. 'I walked out of the meeting feeling uneasy.
'There was no explicit mention that to star in one of those films I had to sleep with him, but the subtext was there.'
She said he later attempted to lure her into a hotel, but she refused - and promptly lost the film he was supposedly willing to finance.
As the story continued to roll, Barack Obama - who received $680,000 in money raised by Weinstein for his 2012 election campaign - joined in the chorus of disapproval, saying he was 'disgusted' with the revelations.
On Tuesday Barack Obama said he was 'disgusted' with the stories about Weinstein (both seen in 2012), who had raised more than $600,000 for Obama after switching from the Hillary camp when she lost in 2008. He's not said whether he would return the money
'Michelle and I have been disgusted by the recent reports about Harvey Weinstein,' Obama said in a statement.
'Any man who demeans and degrades women in such fashion needs to be condemned and held accountable, regardless of wealth or status.'
'We should celebrate the courage of women who have come forward to tell these painful stories,' the former president continued.
'And we all need to build a culture - including by empowering our girls and teaching our boys decency and respect - so we can make such behavior less prevalent in the future.'
He did not say whether he would return the money raised for his campaign.
Hillary Clinton also spoke out on Tuesday, saying she was 'shocked and appalled' about the stories that had emerged about Weinstein.
On Tuesday, it also emerged that Weinstein had approached Jeffrey Katzenberg, former chairman of Walt Disney Studios and CEO of DreamWorks Animation, for help in persuading the board of the Weinstein Company not to fire him.
Katzenberg released the content of his reply - and it likely made for painful reading for the disgraced producer.
Katzenberg and Weinstein, pictured far right and left respectively, have been friends for more than 30 years. He wrote in his letter 'you have done terrible things to a number of women. I am sickened by it'
Weinstein emailed a handful of Hollywood executives, including Katzenberg, on Wednesday in a desperate and last-minute plea for support.
'My board is thinking of firing me. All I'm asking is, let me take a leave of absence and get into heavy therapy and counseling,' wrote Weinstein in the email, which was read by one of the recipients to Janice Min.
'Whether is be in a facility or somewhere else, allow me to resurrect myself with a second chance.'
He went on to state that 'a lot of the allegations are false' before asking that they send an email backing him, which he could in turn present to the company board.
In response, Katzenberg, who has known Weinstein for 30 years, said he had 'no way of knowing' whether the allegations were false, given that the email was sent just days after the NYT expose.
'You have done terrible things to a number of women over a period of years,' he continued.
'I cannot in any way say this is OK with me…It's not at all, and I am sickened by it, angry with you and incredibly disappointed in you.
'I doubt this is what you want to hear from me and most likely you aren’t interested in my advice but this is the way I see it.'
Harvey Weinstein has been slammed with multiple accusations of sexual harassment after a report detailing a $100,000 settlement he reportedly made to Rose McGowan in the mid-'90s emerged this week.
Below are some of the women who have accused Weinstein of harassing them, or other women.
Angelina Jolie said she had to turn down Weinstein's advances as a young actress
Gwyneth Paltrow: The star told the New York Times that Weinstein touched her and suggested having joint massages in the bedroom before she started shooting Emma. She said she told her then boyfriend Brad Pitt about the incident and he confronted the mogul.
Angelina Jolie: Jolie told the Time she had to turn down advances from Weinstein in the late 1990s and she chose never to work with him again. She said she warned other women about him.
Judith Godreche: The French actress says Weinstein tried to massage her and pull off her sweater after asking her up to his Cannes suite to see the view in 1996.
Dawn Dunning: Aspiring actress says she was called to a meeting about future film projects. When she arrived Weinstein presented her with three scripts for his next three movies which he would let her star in, only if she had three-way sex with him. She fled the hotel.
Tomi-Ann Roberts: Weinstein met her when she was serving tables and told her to meet him at his home. When she arrived he was in the bath and told her she would give a better audition if she was naked. She says she refused and left.
Asia Argento: The Italian actress has accused Weinstein of forcibly performing oral sex on her when she was 21. 'He terrified me, and he was big. It wouldn't stop. It was a nightmare.' She said she went on to have consensual sex with him over the years that followed. She documented the alleged attack in her 2000 film Scarlet Diva.
Katherine Kendall: The Swingers actress was told Weinstein had to stop off in his apartment to pick something up after a screening. He changed into a bathrobe and told her to massage her. When she resisted she said the mogul returned naked and chased her.
Lucia Evans: Aspiring actress claims Weinstein forced her to perform oral sex on him. Speaking to the New Yorker, she said that she suffered years of trauma after the incident which occurred in a 'casting meeting' in a Miramax office in Manhattan.
Gwyneth Paltrow revealed that Weinstein attempted to get her into a hotel bedroom and massage her when she was 22
Mira Sorvino: The Mighty Aphrodite actress told the New Yorker that Weinstein tried to massage her in a hotel room at the 1995 Toronto International Film Festival He then went to her home in the middle of the night but she called a male friend to protect her. She said turning down the mogul adversely affected her career.
Rosanna Arquette: The actress also said her career suffered after she rebuffed Weinstein's advances. At a hotel meeting he tried to put her hand on his erect penis, she claims.
Rose McGowan: The actress, who made her breakthrough in 1996 in the Weinstein-produced slasher revival movie Scream, reportedly sued Weinstein after he approached her during production of that movie. She signed a non-disclosure agreement at the close of the suit and has only referred to him obliquely in social media since. On Sunday she referred to being abused by a 'monster' and has previously referred to being raped by a studio head.
Ashley Judd: Judd's film roles include the thriller Kiss the Girls - and she says that during the filming of that movie Weinstein repeatedly asked her to watch him shower. She was one of the women who spoke out to The New York Times this week, saying: 'Women have been talking about Harvey amongst ourselves for a long time, and it's simply beyond time to have the conversation publicly.'
Zelda Perkins was 25 when, as an assistant of Weinstein's in London, she reportedly confronted the mogul for harassing her and 'several' other women; she later settled out of court
Lauren O'Connor: A former employee of The Weinstein Company, she told executives there in the fall of 2015 that there was 'a toxic environment for women at this company' after one of her colleagues told her that Weinstein had pressured her into massaging him while he was naked, the NYT said.
Ambra Battilana: An Italian actress and model, she told the NYT that in March 2015 Weinstein invited her to his New York office. There, she said, he asked if her breasts were real before grabbing them and putting his hands up her skirt. She reported the alleged incident to police, but they did not press charges. According to the NYT, Weinstein later paid her off.
Laura Madden: An ex-employee, she told the NYT that Weinstein had asked her to give him massages from 1991 onwards, while they were both in London and Dublin. 'It was so manipulative,' she told the NYT. 'You constantly question yourself - am I the one who is the problem?' Weinstein denied knowledge.
Emily Nestor: Nestor was a temporary employee of the Weinstein Company for just one day in 2014 when Weinstein approached her and offered to boost her career in exchange for sex, the NYT reported.
Zelda Perkins: An assistant of Weinstein's based in London in 1998; then 25, she reportedly confronted Weinstein after she and 'several' others were harassed and later settled out of court.
Elizabeth Karlsen, an Oscar-winning producer, said a female executive told her almost 30 years ago that she had found Weinstein naked in her bedroom in a Miramax-rented property
Elizabeth Karlsen: The Oscar-nominated producer of Carol and The Crying Game, among others, told The Hollywood Reporter on Sunday that almost 30 years ago, an unnamed young female executive who had worked at Miramax with Weinstein had found him naked in her bedroom one night. The exec was in a house rented by Miramax at the time to cut its overheads.
Liza Campbell: A freelance script reader, she told the UK's Sunday Times that Weinstein had summoned her to his hotel room in London before telling her to get in the bath with him.
Lauren Sivan: The former Fox news host said that Weinstein trapped her in a closed restaurant and masturbated in front of her to completion in 2007. He took her to a closed restaurant beneath a club she had visited and attempted to kiss her, then when she refused he cornered her and made her watch him touch himself, according to The Huffington Post.
Jessica Hynes: The British actress, best known for her roles in the Bridget Jones movies and for co-creating and co-writing the sitcom Spaced, said she was invited to audition for Weinstein when she was 19 - in a bikini. Hynes, formerly known as Jessica Stevenson, said she refused to wear the skimpy item - and lost the job.
Romola Garai: British actress Romola Garai said she felt 'violated' following a meeting with Harvey Weinstein in his London hotel room when she was 18 in which he was in a bathrobe. Garai, best known for her role in 'Atonement', said she had already been hired for a part but was told to audition privately with the Hollywood mogul because 'you had to be personally approved by him'. 'Like every other woman in the industry, I've had an 'audition' with Harvey Weinstein,' she told The Guardian. 'So I had to go to his hotel room in the Savoy and he answered the door in his bathrobe. I was only 18. I felt violated by it'.